Home » Blog » Huntington’s Disease (HD)

Huntington’s Disease (HD)

By Amigos IAS

Why is it in the news?

  • Scientists used genetically engineered fruit flies (Drosophila melanogaster) to probe the molecular intricacies underlying the progression of Huntington’s disease.

About Huntington’s Disease

  • HD is a genetic disorder characterized by its impact on the brain, leading to a triad of symptoms: progressive motor dysfunction, cognitive decline, and psychiatric manifestations.
  • It follows an autosomal dominant pattern of inheritance, meaning that an individual has a 50% chance of inheriting the mutated gene if one parent carries it. The disease typically manifests in mid-adulthood.
  • The root cause of HD lies in a mutation in the huntingtin (HTT) gene. This mutation results in the production of an abnormal form of the huntingtin protein.
  • The huntingtin gene (HTT) was identified in 1993, marking a crucial milestone in understanding the genetic basis of Huntington’s disease.
  • Symptoms:
  • Individuals with HD often exhibit uncontrollable jerking or writhing motions, known as chorea.
  • Difficulties in coordination and balance are common, contributing to the overall motor dysfunction.
  • The disease progresses, impacting essential functions like speech and swallowing.
  • HD affects cognitive abilities, leading to changes in thinking and reasoning.
  • Memory functions are impaired, contributing to the overall cognitive decline.
  • Individuals may experience challenges in concentrating and making decisions.
  • As of now, there is no cure for HD. Treatment strategies focus on managing symptoms to enhance the quality of life for individuals living with HD.

Signup for newsletter

Receive notifications straight into your inbox

Leave a comment

Item added to cart.
0 items - 0.00

Discover more from AMIGOS IAS

Subscribe now to keep reading and get access to the full archive.

Continue reading